Esperienza e Integrazione

Non esistono solo dati, dosaggi e studi randomizzati. La ricerca psichedelica si intreccia profondamente con l’esperienza vissuta, soggettiva, complessa, spesso difficile da descrivere, e con ciò che accade dopo.
In questa sezione sono raccolti articoli e riflessioni che affrontano il tema dell’integrazione, della preparazione e del senso da attribuire a ciò che accade durante e dopo un’esperienza psichedelica.
Uno spazio meno tecnico, ma non meno importante, dove parole come contesto, simbolo, relazione e trasformazione diventano centrali.

Esperienza

Imprinting: expanding the extra-pharmacological model of psychedelic drug action to incorporate delayed influences of sets and settings.
Garel, Nicolas et al. “Imprinting: expanding the extra-pharmacological model of psychedelic drug action to incorporate delayed influences of sets and settings.” Frontiers in human neuroscience vol. 17 1200393. 18 Jul. 2023, doi:10.3389/fnhum.2023.1200393

Co-use of MDMA with psilocybin/LSD may buffer against challenging experiences and enhance positive experiences.
Zeifman, Richard J et al. “Co-use of MDMA with psilocybin/LSD may buffer against challenging experiences and enhance positive experiences.” Scientific reports vol. 13,1 13645. 22 Aug. 2023, doi:10.1038/s41598-023-40856-5

Predicting the Intensity of Psychedelic-Induced Mystical and Challenging Experience in a Healthy Population: An Exploratory Post-Hoc Analysis.
Ko, Kwonmok et al. “Predicting the Intensity of Psychedelic-Induced Mystical and Challenging Experience in a Healthy Population: An Exploratory Post-Hoc Analysis.” Neuropsychiatric disease and treatment vol. 19 2105-2113. 5 Oct. 2023, doi:10.2147/NDT.S426193

Extended difficulties following the use of psychedelic drugs: A mixed methods study.
Evans, Jules et al. “Extended difficulties following the use of psychedelic drugs: A mixed methods study.” PloS one vol. 18,10 e0293349. 24 Oct. 2023, doi:10.1371/journal.pone.0293349

Effects of External Stimulation on Psychedelic State Neurodynamics.
Mediano, Pedro A M et al. “Effects of External Stimulation on Psychedelic State Neurodynamics.” ACS chemical neuroscience vol. 15,3 (2024): 462-471. doi:10.1021/acschemneuro.3c00289

Psychedelics and the ‘inner healer’: Myth or mechanism?
Peill J, Marguilho M, Erritzoe D, et al. Psychedelics and the ‘inner healer’: Myth or mechanism? Journal of Psychopharmacology. 2024;38(5):417-424. doi:10.1177/02698811241239206

Co-administration of midazolam and psilocybin: differential effects on subjective quality versus memory of the psychedelic experience.
Nicholas, C.R., Banks, M.I., Lennertz, R.C. et al. Co-administration of midazolam and psilocybin: differential effects on subjective quality versus memory of the psychedelic experience. Transl Psychiatry 14, 372 (2024). https://doi.org/10.1038/s41398-024-03059-8

Integrazione

Preliminary evidence for the importance of therapeutic alliance in MDMA-assisted psychotherapy for posttraumatic stress disorder.
Zeifman, Richard J et al. “Preliminary evidence for the importance of therapeutic alliance in MDMA-assisted psychotherapy for posttraumatic stress disorder.” European journal of psychotraumatology vol. 15,1 (2024): 2297536. doi:10.1080/20008066.2023.2297536

The association between diverse psychological protocols and the efficacy of psilocybin-assisted therapy for clinical depressive symptoms: a Bayesian meta-analysis.
Chen, Mu-Hong et al. “The association between diverse psychological protocols and the efficacy of psilocybin-assisted therapy for clinical depressive symptoms: a Bayesian meta-analysis.” Frontiers in psychiatry vol. 15 1439347. 13 Aug. 2024, doi:10.3389/fpsyt.2024.1439347

Compass Psychological Support Model for COMP360 Psilocybin Treatment of Serious Mental Health Conditions.
Kirlić, Namik et al. “Compass Psychological Support Model for COMP360 Psilocybin Treatment of Serious Mental Health Conditions.” The American journal of psychiatry vol. 182,1 (2025): 126-132. doi:10.1176/appi.ajp.20230884

Integration of personal psychedelic experiences into clinical practice: A phenomenological study in mental health professionals.
Tadmor, Nir, Demian Halperin, and Guy Simon. "Integration of personal psychedelic experiences into clinical practice: A phenomenological study in mental health professionals". Journal of Psychedelic Studies 9.2 (2025): 136-148. https://doi.org/10.1556/2054.2024.00372 Web.

Psychological support approaches in psychedelic therapy: results from a survey of psychedelic practitioners.
Bender DA, Nayak SM, Siegel JS, et al. Psychological support approaches in psychedelic therapy: results from a survey of psychedelic practitioners. J Clin Psychiatry . 2025;86(1):24m15521.

Combined ketamine and psychotherapy provide no additional benefit beyond ketamine alone in treating depression or PTSD: Evidence from a help-seeking sample.
Moore, Tyler M et al. “Combined ketamine and psychotherapy provide no additional benefit beyond ketamine alone in treating depression or PTSD: Evidence from a help-seeking sample.” Journal of affective disorders vol. 381 (2025): 233-241. doi:10.1016/j.jad.2025.04.041

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