MDMA

La MDMA è una delle sostanze psichedeliche più avanzate nel percorso di sperimentazione clinica, in particolare per il trattamento del disturbo post-traumatico da stress (PTSD).
In questa pagina trovi raccolti gli articoli dedicati ai principali studi clinici e alle riflessioni che emergono attorno al possibile impiego terapeutico di questa molecola.
Una ricerca che continua a sollevare domande importanti, sia sul piano scientifico che etico, e che sta contribuendo in modo significativo al dibattito internazionale sulle terapie psichedeliche.

MDMA-assisted therapy for moderate to severe PTSD: a randomized, placebo-controlled phase 3 trial.
Mitchell, J.M., Ot’alora G., M., van der Kolk, B. et al. MDMA-assisted therapy for moderate to severe PTSD: a randomized, placebo-controlled phase 3 trial. Nat Med 29, 2473–2480 (2023). https://doi.org/10.1038/s41591-023-02565-4

MDMA-assisted psychotherapy for PTSD in adolescents: rationale, potential, risks, and considerations.
Kangaslampi, S., Zijlmans, J. MDMA-assisted psychotherapy for PTSD in adolescents: rationale, potential, risks, and considerations. Eur Child Adolesc Psychiatry 33, 3753–3764 (2024). https://doi.org/10.1007/s00787-023-02310-9

Preliminary evidence for the importance of therapeutic alliance in MDMA-assisted psychotherapy for posttraumatic stress disorder.
Zeifman, Richard J et al. “Preliminary evidence for the importance of therapeutic alliance in MDMA-assisted psychotherapy for posttraumatic stress disorder.” European journal of psychotraumatology vol. 15,1 (2024): 2297536. doi:10.1080/20008066.2023.2297536

Methylone is a rapid-acting neuroplastogen with less off-target activity than MDMA.
Warner-Schmidt, Jennifer et al. “Methylone is a rapid-acting neuroplastogen with less off-target activity than MDMA.” Frontiers in neuroscience vol. 18 1353131. 7 Feb. 2024, doi:10.3389/fnins.2024.1353131

Acute effects of R-MDMA, S-MDMA, and racemic MDMA in a randomized double-blind cross-over trial in healthy participants.
Straumann, I., Avedisian, I., Klaiber, A. et al. Acute effects of R-MDMA, S-MDMA, and racemic MDMA in a randomized double-blind cross-over trial in healthy participants. Neuropsychopharmacol. 50, 362–371 (2025). https://doi.org/10.1038/s41386-024-01972-6

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